Zyprexa and Seroquel also have significant antidepressant effects.Further studies are likely to find antidepressant effects in other atypicals.Because we don’t know exactly how they work and what we should be targeting, it comes as no surprise that their clinical benefit leaves much to be desired, with burdensome side effects ranging from dry mouth to weight gain to tremors to sedation to skin rash.However, a lot of these effects go away as the body adjusts to the medication.
Treatment of bipolar disorder is usually lengthy, often lasting years, although most long-term treatment is limited to simply taking a daily medication to help keep the symptoms of bipolar disorder at bay.
Nevertheless, the APA and other guidelines recommend the atypicals as a first option for treating mania in the initial phase, often in combination with a mood stabilizer.
The same guidelines and product labeling on these medications also recommend gradual tapering following remission, owing to the risk of tardive dyskinesia (involuntary spasms), unless needed.
This is because an antidepressant without a concomitant antimania medication is almost certain to switch a patient into mania.
Some authorities contend that even with an antimania drug, the danger is there.